Left: Expression of glt-3 in the canal cell    Right: Expression of glt-1 around the nerve ring


A Genetic study of Neuronal Signaling, Glutamate Accumulation,

and Stroke-Like Neuro-degeneration in C. elegans

 Our brain is buzzing with neuronal activity. Nerve cells relentlessly fire information at one another, releasing powerful stimulating molecules in the process. How do we keep order in this mayhem? How do we prevent the accumulation of these powerful stimulating signals? What are the pathological events that happen in diseases like stroke, when we do accumulate too much of these signaling molecules? Can we find ways to stop the degenerative process that ensues? These are some of the questions that we study in our lab. To help us tackle these complicated topics, we use the microscopic, free-living nematode C. elegans. Although these worms look very different from humans, they provide an excellent animal model system, because cellular and molecular events are highly conserved in evolution and are very similar in nematodes and humans. This approach offers a set of very powerful research tools. We can use genetic analysis and screen through huge numbers of worms for rare mutants of interest. We also know a lot about their genome, their development and the details of the wiring of their nervous system. We therefore use C. elegans to study Glutamate Transporters, the proteins that prevent the accumulation of dangerous concentrations of the powerful stimulating molecules in the brain, and the process of excitotoxic neurodegeneration that follows their malfunction.       more ササ







Contact Information:

Itzhak Mano, Ph.D.

Physiology, Pharmacology, and Neuroscience
The Sophie Davis School of Biomedical Education
City College, The City University of New York
160 Convent Avenue, New York, NY 10031

Office: Harris Hall, room 309
    Phone:(212)650 7965
    Fax:(212)650 7726
Lab: Marshak building, room 824
   Phone:(212)650 5334

E-mail: imano@ccny.cuny.edu

Physiol. Pharm. & Neurosci, City College, C. elegans @ CUNY


The Mano Lab

Department of Physiology, Pharmacology, & Neuroscience

Sophie Davis Biomedical School, City College, The City University of New York.
Created By Omer Mano